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7.346 | Spring 2013 | Undergraduate

# Virus-host Interactions in Infectious Diseases

WEEK # | TOPICS | READINGS
--- | --- | ---

1 | Host Sensors of Viral Infection-I See the Lecture Summary | No readings

2 | Introduction and Course Overview See the Lecture Summary | Zeng, W., L. Sun, et al. “Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity.” Cell 141, no. 2 (2010): 315–30. Mibayashi, M., L. Martinez-Sobrido, et al. “Inhibition of Retinoic Acid-Inducible Gene I-Mediated Induction of Beta Interferon by the NS1 Protein of Influenza A Virus.” Journal of Virology 81, no. 2 (2007): 514–24.

3 | Host Sensors of Viral Infection-II: The Road to IFN Production Runs through the Mitochondria. See the Lecture Summary | Kawai, T., K. Takahashi, et al. “IPS-1, An Adaptor Triggering RIG-I and Mda5-Mediated Yype-I Interferon Induction.” Nature Immunology 6, no. 10 (2005): 981–8. Li, XD., L. Sun, et al. “Hepatitis C Virus Protease NS3/4A Cleaves Mitochondrial Antiviral Signaling Protein Off the Mitochondria to Evade Innate Immunity.” Proceedings of the National Academy of Sciences 102, no. 49 (2005): 17717–22.

4 | Secreted IFN – In the Extracellular Space, No One Can Hear You Scream See the Lecture Summary | Smith, T. J., and R. R. Wagner. “Rabbit Macrophage Interferons I. Conditions For Biosynthesis By Virus-Infected And Uninfected Cells.” Journal of Experimental Medicine 125, no. 4 (1967): 559–77. Alcamí, A., J. A. Symons, et al. “The Vaccinia Virus Soluble Alpha/Beta Interferon (IFN) Receptor Binds to the Cell Surface and Protects Cells from the Antiviral Effects of IFN.” Journal of Virology 74, no. 23 (2000): 11230–9.

5 | Vaccines: We Win, Finally. Not So Fast See the Lecture Summary | Guirakhoo, F., J. Arroyo, et al. “Construction, Safety, and Immunogenicity in Nonhuman Primates of a Chimeric Yellow Fever-Dengue Virus Tetravalent Vaccine.” Journal of Virology 75, no. 16 (2001): 7290–304. Manley K., J. Anderson, et al. “Human Cytomegalovirus Escapes a Naturally Occurring Neutralizing Antibody by Incorporating It into Assembling Virions.” C_ell Host and Microbe_ 10, no. 3 (2011): 197–209.

6 | Trip to Sanofi/Pasteur See the Lecture Summary | Field Trip—No Readings

7 | A New Player in the Puzzle of Filovirus Entry into Host Cells See the Lecture Summary | Chandran, K., N. J. Sullivan, et al. “Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection.” Science 308, no. 5728 (2005): 1643–5. Carette, J. E., M. Raaben, et al. “Ebola Virus Entry Requires Cholesterol Transporter Niemann Pick-C1.” Nature 477, no. 7364 (2011): 340–3.

8 | IFN Signaling: United STATs and the Rule of V See the Lecture Summary | Leung, S., S. A. Qureshi, et al. “Role of STAT2 in the Alpha Interferon Signaling Pathway.” Molecular and Cellular Biology 15, no. 3 (1995): 1312–7. Rodriguez, J. J., J. P. Parisien, et al. “Nipah Virus V Protein Evades Alpha and Gamma Interferons by Preventing STAT1 and STAT2 Activation and Nuclear Accumulation.” Journal of Virology 76, no. 22 (2002): 11476–83.

9 | Mechanisms of Human Cytomegalovirus Infection and Restriction See the Lecture Summary | Chin, K., and P. Cresswell. “Viperin (cig5), An IFN-inducible Antiviral Protein Directly Induced By Human Cytomegalovirus.” Proceedings of the National Academy of Sciences 98, no. 26 (2001): 15125–30. Seo, J., R. Yaneva, et al. “Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity.” Science 332, no. 6033 (2011):1093–7.

10 | HIV Restriction Factors and Mechanism of Evasion See the Lecture Summary | Perez-Caballero, D., T. Zang, et al. “Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells.” Cell 139, no. 3 (2009): 499–511. Mitchell, R. S., C. Katsura, et al. “Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking.” PLoS Pathogens 5, no. 5 (2009): e1000450.

11 | Interferon-Induced Transmembrane (IFITM) Proteins as Restriction Factors for Influenza Virus See the Lecture Summary | Brass, A. L., I. Huang, et al. “The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus.” Cell 139, no. 7 (2009): 1243–54. Everitt A. R., S. Clare, et al. “IFITM3 Restricts The Morbidity and Mortality Associated With Influenza.” Nature 484, no. 7395 (2012): 519–23.

12 | End-Term Final Assignment See the Lecture Summary | Final Assignment Due—No Readings

## Course Info

##### Instructors

- Dr. Sumana Sanyal
- Dr. Joseph Ashour

##### Departments

- Biology

##### As Taught In

Spring 2013

##### Level

Undergraduate

##### Topics

- Science
  - Biology
    - Cell Biology
    - Molecular Biology
    - Virology

##### Learning Resource Types

co_present Instructor Insights

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