GIVE NOW about ocw help & faqs contact us
7.51 | Fall 2001 | Graduate

# Graduate Biochemistry

Lec # | Topics | Instructors
--- | --- | ---

1 | Reaction models; simple kinetics & equilibria | Bob Sauer

2 | Analyzing kinetic & equilibria experiments |

3 | Free energy, entropy, enthalpy & cycles |

4 | Forces, hydrophobic effect, chelate effect |

5 | Molecular structure and dynamics |

6 | Physical properties of proteins and nucleic acids | Tania Baker

7 | Principles and practice of protein purification |

8 | Principles and practice of protein purification (cont.) |

9 | EXAM 1 |

10 | Domain & subunit organization; molecular weight determination | Tania Baker

11 | Macromolecular interactions: specificity, affinity and energetics |

12 | Macromolecular interactions: specificity, affinity and energetics (cont.) |

13 | Enzyme catalysis: kinetics | Frank Solomon

14 | Mechanism of enzyme catalyzed reactions |

15 | inhibition and intermediates |

16 | Mechanism of enzyme catalyzed reactions: chemistry |

17 | Mechanism of enzyme catalyzed reactions: partitioning & exchange |

18 | Mechanism of enzyme catalyzed reactions: binding energy |

19 | Specificity of catalysis: energetics and consequences |

20 | Specificity of catalysis: energetics and consequences (cont.) |

21 | EXAM 2 |

22 | Coupled vectorial processes: making ATP | Frank Solomon

23 | Coupled vectorial processes: pumps |

24 | Coupled vectorial processes: OxPhos, morphology to enzymology |

25 | Coupled vectorial processes: processivity |

26 | Coupled vectorial processes: Motors; Polymers – origins & consequences of structural & thermodynamic polarity |

27 | Coupled vectorial processes: motors; structural & thermodynamic polarity |

28 | Coupled vectorial processes: protein folding |

29 | Review Session |

30 | FINAL EXAM |

## Course Info

##### Instructors

- Prof. Bob Sauer
- Prof. Frank Solomon
- Prof. Tania Baker

##### Departments

- Biology

##### As Taught In

Fall 2001

##### Level

Graduate

##### Topics

- Science
  - Biology
    - Biochemistry

##### Learning Resource Types

notes Lecture Notes

Browse Resources

# You are leaving MIT OpenCourseWare

Please be advised that external sites may have terms and conditions, including license rights, that differ from ours. MIT OCW is not responsible for any content on third party sites, nor does a link suggest an endorsement of those sites and/or their content.