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9.322J | Fall 2005 | Graduate

# Genetic Neurobiology

SES # | Topics | READINGS
--- | --- | ---

1 | Introduction to Course |

2 | Bacterial Chemoreception |

3 | Student Presentations | Berg, H. C. “Bacterial microprocessing.” Cold Spring Harb Symp Quant Biol 55 (1990): 539-45. Adler, J. “Chemoreceptors in bacteria.” Science 166, no. 913 (December 26, 1969): 1588-97. Oosawa, K., J. F. Hess, and M. I. Simon. “Mutants defective in bacterial chemotaxis show modified protein phosphorylation.” Cell 53, no. 1 (April 8, 1988): 89-96.

4 | Bacterial and Paramecium Motility | Zhang, Y., H. Lu, and C. I. Bargmann. “Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans.” Nature 438, no. 7065 (November 10, 2005): 179-84.

5 | Student Presentations | Berg, H. C. “The rotary motor of bacterial flagella.” Annu Rev Biochem 72 (2003): 19-54. Epub December 11, 2002. Blair, D. F., and H. C. Berg. “Restoration of torque in defective flagellar motors.” Science 242, no. 4886 (December 23, 1988): 1678-81. Meister, M., G. Glowe, and H. C. Berg. “The proton flux through the bacterial flagellar motor.” Cell 49, no. 5 (June 5, 1987): 643-50.

6 | Neurogenomics: Genome Sequencing and the Nervous System | Carpenter, A. E., and D. M. Sabatini. “Systematic genome-wide screens of gene function.” Nat Rev Genet 5, no. 1 (January 2004): 11-22. Palladino, M. J., L. P. Keegan, M. A. O’Connell, and R. A. Reenan. “A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity.” Cell 102, no. 4 (August 18, 2000): 437-49. Hoopengardner, B., T. Bhalla, C. Staber, and R. Reenan. “Nervous system targets of RNA editing identified by comparative genomics.” Science 301, no. 5634 (August 8, 2003): 832-6.

7 | Student Presentations |

8 | Development of the Nervous System |

9 | Student Presentations |

10 | Genetic Analysis of Axonal Pathfinding Student Presentations |

11 | Genetic Analysis of Membrane Excitability Student Presentations |

12 | Neurodevelopment and Function in the Mouse | Kano, M., K. Hashimoto, C. Chen, A. Abeliovich, A. Aiba, H. Kurihara, M. Watanabe, Y. Inoue, and S. Tonegawa. “Impaired synapse elimination during cerebellar development in PKC gamma mutant mice.” Cell 83, no. 7 (December 29, 1995): 1223-31. Caviness, V. S. “Reeler mutant mouse: a genetic experiment in developing mammalian cortex.” Soc Neurosci Symp 2 (1977): 27-46.

13 | Student Presentations |

14 | Neurotransmitter Release at Nerve Terminals |

15 | Student Presentations |

16 | Genetic Analysis of Sensory Perception |

17 | Student Presentations |

18 | Higher Brain Function in Drosophila: Learning and Circadian Rhythms | Konopka, R. J., and S. Benzer. “Clock mutants of Drosophila melanogaster.” Proc Natl Acad Sci U.S.A. 68, no. 9 (September, 1971): 2112-6. Waddell, S., J. D. Armstrong, T. Kitamoto, K. Kaiser, and W. G. Quinn. “The amnesiac gene product is expressed in two neurons in the Drosophila brain that are critical for memory.” Cell 103, no. 5 (November 22, 2000): 805-13.

19 | Student Presentations |

20 | Synapse Formation in Vertebrates and Invertebrates Student Presentations |

21 | Genetic Analysis of Learning and Memory in Mice |

22 | Student Presentations | Nakazawa, K., M. C. Quirk, R. A. Chitwood, M. Watanabe, M. F. Yeckel, L. D. Sun, A. Kato, C. A. Carr, D. Johnston, M. A. Wilson, and S. Tonegawa. “Requirement for hippocampal CA3 NMDA receptors in associative memory recall.” Science 297, no. 5579 (July 12, 2002): 211-8. Epub May 30, 2002.

23 | Neurogenetics in Humans: Memory and Disease |

24 | Student Presentations | Millar, J. K., B. S. Pickard, S. Mackie, R. James, S. Christie, S. R. Buchanan, M. P. Malloy, J. E. Chubb, E. Huston, G. S. Baillie, P. A. Thomson, E. V. Hill, N. J. Brandon, J. C. Rain, L. M. Camargo, P. J. Whiting, M. D. Houslay, D. H. Blackwood, W. J. Muir, and D. J. Porteous. “DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.” Science 310, no. 5751 (November 18, 2005): 1187-91.

## Course Info

##### Instructors

- Prof. Troy Littleton
- Prof. William Quinn

##### Departments

- Brain and Cognitive Sciences
- Biology

##### As Taught In

Fall 2005

##### Level

Graduate

##### Topics

- Science
  - Biology
    - Genetics
    - Neurobiology

##### Learning Resource Types

assignment Written Assignments
assignment Presentation Assignments

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