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9.013J | Spring 2008 | Graduate

# Cell and Molecular Neurobiology

In each class session, one student gives a presentation on an assigned paper. The following table lists the assigned papers for each session.

LEC # | TOPICS | PAPERS USED IN STUDENT PRESENTATIONS
--- | --- | ---

1 | Ion channels I | None

2 | Ion channels II | Doyle, Declan A., J. M. Cabral, R. A. Pfuetzner, et al. “The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity.” Science 280 (April 3, 1998): 69-77.

3 | Receptors I | Corey, David P., Jaime Garcia-Anoveros, Jeffrey R. Holt, et al. “TRPA1 is a Candidate for the Mechanosensitive Transduction Channel of Vertebrate Hair Cells.” Nature 432 (December 9, 2004): 723-730.

4 | Receptors II | He, Li, Jamie Fong, Mark von Zastrow, and Jennifer L. Whistler. “Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization.” Cell 108 (January 25, 2002): 271-282.

5 | Introduction; basics of electrophysiology | Mayer, Mark L., Gary L. Westbrook, and Peter B. Guthrie. “Voltage-dependent Block by Mg2+ of NMDA Responses in Spinal Cord Neurons.” Nature 309 (May 17, 1984): 261-263.

6 | Modulation of receptor activity | Bibb, James A., Gretchen L. Snyder, Akinori Nishi, et al. “Phosphorylation of DARPP-32 by Cdk5 Modulates Dopamine Signaling in Neurons.” Nature 402 (December 9, 1999): 669-671.

7 | Protein targeting, signaling complexes | Tsunoda, Susan, Jimena Sierralta, Yumei Sun, et al. “A Multivalent PDZ-domain Protein Assembles Signaling Complexes in a G-Protein-coupled Cascade.” Nature 388 (July 17, 1997): 243-249.

8 | Neuronal polarity / subcellular specialization | Fivaz, Marc, Samuel Bandara, Takanari Inoue, and Tobias Meyer. “Robust Neuronal Symmetry Breaking by Ras-Triggered Local Positive Feedback.” Nature 388 (July 17, 1997): 243-249.

9 | Repertoire of neuron interactions | Flames, Nuria, Jason E. Long, Alistair N. Garratt, et al. “Short- and Long-range Attraction of Cortical GABAergic Interneurons by Neuregulin-1.” Neuron 44 (October 14, 2004): 251-261.

10 | Neurogenesis | Xie, Zhigang, et al. “Cep120 and TACCs Control Interkinetic Nuclear Migration and the Neural Progenitor Pool.” Neuron 56 (October 4, 2007): 79-93.

11 | Presynaptic mechanisms | Yoshihara, Motojiro, and J. Troy Littleton. “Synaptotagmin I Functions as a Calcium Sensor to Synchronize Neurotransmitter Release.” Neuron 36 (December 5, 2002): 897-908.

12 | Molecular manipulation of neural circuits | Callaway, Edward M. “A Molecular and Genetic Arsenal for Systems Neuroscience.” TRENDS in Neurosciences 28, no. 4 (April 2005): 196-201. DeFalco, Jeff, Mark Tomishima, Hongyan Liu, et al. “Virus-assisted Mapping of Neural Inputs to a Feeding Center in the Hypothalamus.” Science 291 (March 30, 2001): 2608-2613. Nakashiba, Toshiaki, Jennie Z. Young, Thomas J. McHugh, et al. “Transgenic Inhibition of Synaptic Transmission Reveals Role of CA3 Output in Hippocampal Learning.” Science 319, no. 5867 (February 29, 2008): 1260-1264. Boyden Edward S., Feng Zhang, Ernst Bamberg, et al. “Millisecond-timescale, Genetically Targeted Optical Control of Neural Activity.” Nature Neuroscience 8, no. 9 (September 2005): 1263-1268. Karpova, Alla Y., Dougal G. R. Tervo, Noah W. Gray, et al. “Rapid and Reversible Chemical Neurotechnique Inactivation of Synaptic Transmission in Genetically Targeted Neurons.” Neuron 48, no. 5 (December 8, 2005): 727-735. Tan, Elaine M., Yoshiaki Yamaguchi, Gregory D. Horwitz, et al. “Selective and Quickly Neurotechnique Reversible Inactivation of Mammalian Neurons In vivo Using the Drosophila Allatostatin Receptor.” Neuron 51, no. 2 (July 20, 2006): 157-170.

13 | Axon guidance | Hedgecock, Edward M., Joseph G. Culotti, and David H. Hall. “The unc-5, unc-6, and unc-40 Genes Guide Circumferential Migrations of Pioneer Axons and Mesodermal Cells on the Epidermis in C. elegans.” Neuron 4, no. 1 (January 1990): 61-85.

14 | Synapse formation/elimination | Kasthuri, Narayanan, and Jeff W. Lichtman. “The Role of Neuronal Identity in Synaptic Competition.” Nature 424 (July 24, 2003): 426-430.

15 | Trophic factors | Zhang, Xiao-hui, and Mu-ming Poo. “Localized Synaptic Potentiation by BDNF Requires Local Protein Synthesis in the Developing Axon.” Neuron 36, no. 4 (November 14, 2002): 675-688.

16 | Postsynaptic mechanisms; LTP/LTD | Shi, Song-Hai, Yasunori Hayashi, Jose A. Esteban, et al. “Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons.” Cell 105, no. 3 (May 4, 2001): 331-343.

17 | Waves and chemoaffinity | McLaughlin, Todd, Christine L. Torborg, Marla B. Feller, et al. “Retinotopic Map Refinement Requires Spontaneous Retinal Waves during a Brief Critical Period of Development.” Neuron 40, no. 6 (December 18, 2003): 1147–1160.

18 | Two faces of GABA | Gulledge, Allan T., and Greg J. Stuart. “Excitatory Actions of GABA in the Cortex.” Neuron 37, no. 2 (January 23, 2003): 299-309.

19 | Hodgkin and Huxley (lecture 1) | Long, Stephen B., Xiao Tao, Ernest B. Campbell, and Roderick MacKinnon. “Atomic Structure of a Voltage-dependent K+ Channel in a Lipid Membrane-like Environment.” Nature 450 (November 15, 2007).

20 | Hodgkin and Huxley (lecture 2) | Zagotta, William N., Toshinori Hoshi, and Richard W. Aldrich. “Restoration of Inactivation in Mutants of Shaker Potassium Channels by a Peptide Derived from ShB.” Science 250, no. 4980 (October 26, 1990): 568-571.

21 | Aplysia learning | Lee, Seung-Hee, Chae-Seok Lim, Hyungju Park, et al. “Nuclear Translocation of CAM-Associated Protein Activates Transcription for Long-Term Facilitation in Aplysia.” Cell 129, no. 4 (May 18, 2007): 801-812.

22 | Drosophila learning | Yu, Dinghui, Alex C. Keene, Anjana Srivatsan, et al. “Drosophila DPM Neurons Form a Delayed and Branch-Specific Memory Trace after Olfactory Classical Conditioning.” Cell 123, no. 5 (December 2, 2005): 945-957.

23 | Drosophila circadian rhythms | Shafer, Orie T., Dong Jo Kim, Richard Dunbar-Yaffe, et al. “Widespread Receptivity to Neuropeptide PDF throughout the Neuronal Circadian Clock Network of Drosophila Revealed by Real-Time Cyclic AMP Imaging.” Neuron 58, no. 2 (April 24, 2008): 223-237.

24 | Epilepsy | Khalilov, Ilgam, Gregory L. Holmes, and Yehezkel Ben-Ari. “In vitro formation of a Secondary Epileptogenic Mirror Focus by Interhippocampal Propagation of Seizures.” Nature Neuroscience 6, no. 10 (October 2003): 1079-1085.

## Course Info

##### Instructors

- Prof. Martha Constantine-Paton
- Prof. Morgan Sheng
- Prof. William Quinn

##### Departments

- Brain and Cognitive Sciences
- Biology

##### As Taught In

Spring 2008

##### Level

Graduate

##### Topics

- Science
  - Biology
    - Cell Biology
    - Molecular Biology
    - Neurobiology

##### Learning Resource Types

assignment Presentation Assignments

Browse Resources

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