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7.341 | Fall 2018 | Undergraduate

# Biomaterials and Devices for Disease Diagnosis and Therapy

Week # | topics | READINGS
--- | --- | ---

1 | Introduction to Biomaterials See the Lecture Summary | [No Readings]

2 | Vaccine Delivery from Biodegradable Microspheres See the Lecture Summary | Feng L, Qi XR, Zhou XJ, Maitani Y, Wang SC, Jiang Y, Nagai T. Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres. J Control Release 2006;112:35-42. doi: 10.1016/j.jconrel.2006.01.012 Jaganathan KS, Rao YU, Singh P, Prabakaran D, Gupta S, Jain A, Vyas SP. Development of a single dose tetanus toxoid formulation based on polymeric microspheres: a comparative study of poly(d,l-lactic-co-glycolic acid) versus chitosan microspheres. Int J Pharm 2005;294:23-32. doi: 10.1016/j.ijpharm.2004.12.026

3 | Advanced Techniques for Improving Vaccine Efficacy See the Lecture Summary | Sullivan SP, Koutsonanos DG, Del Pilar Martin M, Lee JW, Zarnitsyn V, Choi SO, Murthy N, Compans RW, Skountzou I, Prausnitz MR. Dissolving polymer microneedle patches for influenza vaccination. Nat Med 2010;16:915-20. doi: 10.1038/nm.2182 Chahal JS, Khan OF, Cooper CL, McPartlan JS, Tsosie JK, Tilley LD, Sidik SM, Lourido S, Langer R, Bavari S, Ploegh HL, Anderson DG. Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose. Proc Natl Acad Sci U S A 2016;113:E4133-42. doi: 10.1073/pnas.1600299113

4 | State-of-the-art Cancer Vaccines (Part 1) See the Lecture Summary | Qian Y, Jin H, Qiao S, Dai Y, Huang C, Lu L, Luo Q, Zhang Z. Targeting dendritic cells in lymph node with antigen peptide-based nanovaccine for immunotherapy. Biomaterials 2016;98:171-83. doi: 10.1016/j.biomaterials.2016.05.008

5 | State-of-the-art Cancer Vaccines (Part 2) See the Lecture Summary | Tang L, Zheng Y, Melo MB, Mabardi L, Castaño AP, Xie YQ, Li N, Kudchodkar SB, Wong HC, Jeng EK, Maus MV, Irvine DJ. Enhancing T Cell Therapy through TCR-signaling-responsive nanoparticle drug delivery. Nat Biotechnol 2018;36:160-9. doi: 10.1038/nbt.4181

6 | Diagnostic Tools for Infectious Diseases See the Lecture Summary | Kang DK, Ali MM, Zhang K, Huang SS, Peterson E, Digman MA, Gratton E, Zhao W. Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection. Nat Commun 2014;13:5427. doi: 10.1038/ncomms6427 Shafiee H, Jahangir M, Inci F, Wang S, Willenbrecht RB, Giguel FF, Tsibris AM, Kuritzkes DR, Demirci, U. Acute on-chip HIV detection through label-free electrical sensing of viral nano-lysate. Small 2013;9:2553-63. doi: 10.1002/smll.201202195

7 | Islet Cell Encapsulation for Diabetes See the Lecture Summary | Suzuki K, Bonner-Weir S, Trivedi N, Yoon KH, Hollister-Lock J, Colton CK, Weir GC. Function and survival of macroencapsulated syngeneic islets transplanted into streptozocin-diabetic mice. Transplantation 1998;66:21-8. Vegas AJ, Veiseh O, Doloff JC, Ma M, Tam HH, Bratlie K, Li J, Bader AR, Langan E, Olejnik K, Fenton P, Kang JW, Hollister-Locke J, Bochenek MA, Chiu A, Siebert S, Tang K, Jhunjhunwala S, Aresta-Dasilva S, Dholakia N, Thakrar R, Vietti T, Chen M, Cohen J, Siniakowicz K, Qi M, McGarrigle J, Graham AC, Lyle S, Harlan DM, Greiner DL, Oberholzer J, Weir GC, Langer R, Anderson DG. Combinatorial hydrogel library enables identification of materials that mitigate the foreign body reaction response in primates. Nat Biotechnol 2016;34:345-52. doi: 10.1038/nbt.3462

8 | Visit to Sigilon Therapeutics See the Lecture Summary | [No Readings]

9 | Tissue-instructive Scaffolds See the Lecture Summary | Ott HC, Matthiesen TS, Goh SK, Black LD, Kren SM, Netoff TI, Taylor DA. Perfusion-decellularized matrix: using nature’s platform to engineer a bioartificial heart. Nat Med 2008;14:213-21. doi: 10.1038/nm1684 Huang L, Zhu L, Shi X, Xia B, Liu Z, Zhu S, Yang Y, Ma T, Cheng P, Luo K, Huang J, Luo Z. A compound scaffold with uniform longitudinally oriented guidance cues as a porous sheath promotes peripheral nerve regeneration in vivo. Acta Biomater 2018;68:223-36. doi: 10.1016/j.actbio.2017.12.010

10 | Diagnostic Tools for Cancer See the Lecture Summary | Fan R, Vermesh O, Srivastava A, Yen BK, Qin L, Ahmad H, Kwong GA, Liu CC, Gould J, Hood L, Heath JR. Integrated Blood Barcode Chips. Nat Biotechnol 2008;26:1373-8. doi: 10.1038/nbt.1507 Che J, Yu V, Garon EB, Goldman JW, Di Carol D. Biophysical isolation and identification of circulating tumor cells. Lab Chip 2017;17:1452-61. doi: 10.1039/c7lc00038c

11 | Low-cost, Paper-based Diagnostic Tools See the Lecture Summary | Martinez AW, Phillips ST, Whitesides GM. Three-dimensional microfluidic devices fabricated in layered paper and tape. Proc Natl Acad Sci USA 2008;105:19606-11. doi: 10.1073pnas.0810903105 Dungchai W, Chailapakul O, Henry CS. Electrochemical detection for Paper-Based Microfluidics. Anal Chem 2009;81:5821-6. doi: 10.1021/ac9007573

12 | Non-viral Delivery of Genetic Material for Gene Therapy and Cancer See the Lecture Summary | Sharei A, Zoldan J, Adamo A, Sim WY, Cho N, Jackson E, Mao S, Schneider S, Han MJ, Lytton-Jean A, Basto PA, Jhunjhunwala S, Lee J, Heller DA, Kang JW, Hartoularos GC, Kim KS, Anderson DG, Langer R, Jensen KF. A vector-free microfluidic platform for intracellular delivery. Proc Natl Acad Sci USA 2013;110:2082-7. doi: 10.1073/pnas.1218705110 Oberli MA, Reichmuth AM, Dorkin JR, Mitchell MJ, Fenton OS, Jaklenec A, Anderson DG, Langer R, Blankschtein D. Lipid nanoparticle assisted mRNA delivery for potent cancer immunotherapy. Nano Lett 2017;17;1326-35. doi: 10.1021/acs.nanolett.6b03329

13 | Oral Presentations, Conclusion, and Closing Remarks See the Lecture Summary | [No Readings]

## Course Info

##### Instructors

- Dr. Kevin McHugh
- Dr. Ali Beyzavi

##### Departments

- Biology

##### As Taught In

Fall 2018

##### Level

Undergraduate

##### Topics

- Engineering
  - Biological Engineering
    - Biomaterials
    - Cell and Tissue Engineering
- Health and Medicine
  - Cancer
  - Immunology
- Science
  - Biology
    - Cell Biology

##### Learning Resource Types

assignment Presentation Assignments
assignment Written Assignments

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