GIVE NOW about ocw help & faqs contact us
7.341 | Fall 2022 | Undergraduate

# Microbes at War: The Mechanisms That Drive Infectious Diseases

See the Lecture Summaries to read about the discussions that took place around each week’s readings.

Week | Topics | Readings
--- | --- | ---
1 | Welcome to the “Battlefield”—Introduction to Host-Pathogen Interactions and How to Effectively Read Journal Articles | [No Readings]
2 | Identify the Enemy—Koch’s Postulates | Marshall B.J., Armstrong J.A., McGechie D.B., et al. Attempt to fulfill Koch’s postulates for pyloric Campylobacter. Med. J. Aust. 1985. 142 (8) : 436–9. doi: 10.5694/j.1326-5377.1985.tb113443.x. PMID: 3982345. Ohnishi N., Yuasa H., Tanaka S., et al. Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc. Natl. Acad. Sci. U S A. 2008. 105 (3) : 1003–8. doi: 10.1073/pnas.0711183105. Epub 2008 Jan 11. PMID: 18192401; PMCID: PMC2242726.
3 | The World’s Deadliest Infectious Disease—Tuberculosis | Riley R.L., Mills C.C., Nyka W., et al. Aerial dissemination of pulmonary tuberculosis. A two-year study of contagion in a tuberculosis ward. 1959. Am. J. Epidemiol. 1995, 142 (1) : 3–14. doi: 10.1093/oxfordjournals.aje.a117542. PMID: 7785671. Baranowski C., Welsh M.A., Sham L.T., et al. Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape. Elife. 2018. 7:e37516. doi: 10.7554/eLife.37516. PMID: 30324906; PMCID: PMC6231781.
4 | On the Front Lines—How Bacteria Can Stake Their Claim on the Battlefield | Zhou G., Mo W.J., Sebbel P., et al. Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH binding. J. Cell. Sci. 2001. 114 (Pt 22) : 4095–103. doi: 10.1242/jcs.114.22.4095. PMID: 11739641. Spaulding C.N., Klein R.D., Ruer S., et al. Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist. Nature. 2017. 546 (7659) : 528–532. doi: 10.1038/nature22972. Epub 2017 Jun 14. PMID: 28614296; PMCID: PMC5654549.
5 | Not All Microbes Are Bad —Field Trip Preparation | Kehe, J., Ortiz, A., Kulesa, A., et al. Positive interactions are common among culturable bacteria. Sci. Adv., 7 (45), eabi7159.PMCID: PMC8570599, DOI: 10.1126/sciadv.abi7159 Ackerman, C.M., Myhrvold, C., Thakku, S.G., et al. Massively multiplexed nucleic acid detection with Cas13. Nature, 582 (7811), 277–282. PMCID: PMC7332423, DOI: 10.1038/s41586-020-2279-8
6 | Field Trip!!! Concerto Biosciences Written Assignment Due | [No Readings]
7 | Preprint Week—and the Mysterious Hepatitis Outbreak | Morfopoulou S., Buddle S., Torres Montaguth O., et al. Genomic investigations of acute hepatitis of unknown aetiology in children. Nature. 2023. 617 : 564–73. doi: 10.1038/s41586-023-06003-w. Ho A., Orton R., Tayler R., et al. Adeno-associated virus 2 infection in children with non-A-E hepatitis. Nature. 2023. 617 : 555-63. doi: 10.1038/s41586-023-05948-2.
8 | Illness Is Sweeping through the Ranks—Norovirus (Winter Vomiting Bug) | Orchard R.C., Wilen C.B., Doench J.G., et al. Discovery of a proteinaceous cellular receptor for a norovirus. Science. 2016. 353 (6302) : 933–6. doi: 10.1126/science.aaf1220. Epub 2016 Aug 18. PMID: 27540007; PMCID: PMC5484048. Graziano V.R., Walker F.C., Kennedy E.A., et al. CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus. PLoS Pathog. 2020. 16 (4) : e1008242. doi: 10.1371/journal.ppat.1008242. PMID: 32251490; PMCID: PMC7162533.
9 | Biological Sex, Pregnancy, and Infectious Diseases—Malaria | Salanti A., Dahlbäck M., Turner L., et al. Evidence for the involvement of VAR2CSA in pregnancy-associated malaria. J. Exp. Med. 2004. 200 (9) : 1197–203. doi: 10.1084/jem.20041579. PMID: 15520249; PMCID: PMC2211857. Keen J., Serghides L., Ayi K., et al. HIV impairs opsonic phagocytic clearance of pregnancy-associated malaria parasites. PLoS Med. 2007. 4 (5) : e181. doi: 10.1371/journal.pmed.0040181. PMID: 17535103; PMCID: PMC1880852.
10 | Friendly Fire–How the Immune System Can Go Awry, and a Tick Bite Can Lead to Allergic Reactions to Meat Final Presentation Topic Due | Chung C.H., Mirakhur B., Chan E., et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose. N. Engl. J. Med. 2008. 358 (11) : 1109–17. doi: 10.1056/NEJMoa074943. PMID: 18337601; PMCID: PMC2361129. Commins S.P., Satinover S.M., Hosen J., et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. J. Allergy Clin. Immunol. 2009. 123 (2) : 426–33. doi: 10.1016/j.jaci.2008.10.052. Epub 2008 Dec 13. PMID: 19070355; PMCID: PMC3324851.
11 | A Battle You Have Been a Part of—The Global Fight Against COVID-19 | Zazhytska M., Kodra A., Hoagland D.A., et al. Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia. Cell. 2022. 185 (6) : 1052–1064.e12. doi: 10.1016/j.cell.2022.01.024. Epub 2022 Feb 2. PMID: 35180380; PMCID: PMC8808699. Bastard P., Rosen L.B., Zhang Q., et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020. 370 (6515) : eabd4585. doi: 10.1126/science.abd4585. Epub 2020 Sep 24. PMID: 32972996; PMCID: PMC7857397.
12 | What is Your Favorite (or Least Favorite) Microbe? | [No Readings]
13 | The Final Battle—Oral Presentations | [No Readings]

## Course Info

##### Instructor

- Dr. Lisa McLellan

##### Departments

- Biology

##### As Taught In

Fall 2022

##### Level

Undergraduate

##### Topics

- Health and Medicine
  - Immunology
- Science
  - Biology
    - Biochemistry
    - Cell Biology
    - Genetics
    - Microbiology

##### Learning Resource Types

assignment Written Assignments
assignment Presentation Assignments
co_present Instructor Insights

# You are leaving MIT OpenCourseWare

Please be advised that external sites may have terms and conditions, including license rights, that differ from ours. MIT OCW is not responsible for any content on third party sites, nor does a link suggest an endorsement of those sites and/or their content.