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7.342 | Fall 2022 | Undergraduate

# Synapse Remodeling in Health and Disease

See the Lecture Summaries to read about the discussions that took place around each week’s readings.

Week | Topics | Readings
--- | --- | ---
1 | Introduction | [No readings]
2 | Synapse Plasticity: Developing Brain | Johnson C.M., Loucks F.A., Peckler H., et al. (2016). Long-range orbitofrontal and amygdala axons show divergent patterns of maturation in the frontal cortex across adolescence. Dev. Cogn. Neurosci., 18: 113–120. Counotte, D.S., Li K.W., Wortel J., et al. (2010). Changes in molecular composition of rat medial prefrontal cortex synapses during adolescent development. Eur. J. Neurosci., 32(9): 1452–60. Week 2 Reading Questions (PDF)
3 | Synapse Plasticity: Aging Brain | Mostany R., Anstey J.E., Crump K.L., et al. (2013). Altered synaptic dynamics during normal brain aging. J. Neurosci., 33(9): 4094–4104. Eavri R., Shepherd J., Welsh C.A., et al. (2018). Interneuron Simplification and Loss of Structural Plasticity As Markers of Aging-Related Functional Decline. J. Neurosci., 38(39): 8421–32. Week 3 Reading Questions (PDF)
4 | Sensory Experience-Dependent Plasticity—Part 1 | van Versendaal D., Rajendran R., Saiepour M.H., et al. (2012). Elimination of inhibitory synapses is a major component of adult ocular dominance plasticity. Neuron, 74(2): 374–83. Tan H.L., Roth R.H., Graves A.R., et al. (2020). Lamina-specific AMPA receptor dynamics following visual deprivation in vivo. eLife 9:e52420. Week 4 Reading Questions (PDF)
5 | Sensory Experience-Dependent Plasticity—Part 2 | Wilbrecht L., Holtmaat A., Wright N., et al. (2010). Structural plasticity underlies experience-dependent functional plasticity of cortical circuits. J. Neurosci., 30(14): 4927–32. Seaton, G., Hodges, G., de Haan, A., et al. (2020). Dual-Component Structural Plasticity Mediated by αCaMKII Autophosphorylation on Basal Dendrites of Cortical Layer 2/3 Neurons. J. Neurosci., 40(11): 2228–45. Week 5 Reading Questions (PDF)
6 | Learning-Induced Synaptic Plasticity | Johnson C.M., Peckler H., Tai L.H., et al. (2016). Rule learning enhances structural plasticity of long-range axons in frontal cortex. Nat. Commun., 7, 10785: 1–14. Roth R.H., Cudmore R.H., Tan H.L., et al. (2020). Cortical Synaptic AMPA Receptor Plasticity during Motor Learning. Neuron, 105(5): 895–908. Week 6 Reading Questions (PDF)
7 | Neurodevelopmental Disorders: Autism and Fragile X Syndrome | Arroyo E.D., Fiole D., Mantri S.S., et al. (2019). Dendritic spines in early postnatal Fragile X mice are insensitive to novel sensory experience. J. Neurosci., 39(3): 412–19. Krueger D.D., Osterweil E.K., Chen S.P., et al. (2011). Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome. PNAS, 108(6): 2587–92. Week 7 Reading Questions (PDF)
8 | Workshop Mock Grant Proposals Rough draft of mock grant proposal due | [No Readings]
9 | Neurodegeneration: Alzheimer’s Disease Final draft of mock grant proposal due | Lesne S., Koh M., Kotilinek L., et al. (2006). A specific amyloid-β protein assembly in the brain impairs memory. Nature, 440: 352–57. Wu H.Y., Hudry E., Hashimoto T., et al. (2010). Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. J. Neurosci., 30(7): 2636–49. Week 9 Reading Questions (PDF)
10 | Injury: Peripheral Nerve Injury and Traumatic Brain Injury | Sen T., Gupta R., Kaiser H., et al. (2017). Activation of PERK elicits memory impairment through inactivation of CREB and downregulation of PSD95 after traumatic brain injury. J. Neurosci., 37(24): 5900–5911. Ko H., Choi J.H., Park D.I., et al. (2018). Rapid turnover of cortical NCAM1 regulates synaptic reorganization after peripheral nerve injury. Cell Reports, 22: 748–59. Week 10 Reading Questions (PDF)
11 | Field Trip to Vertex Pharmaceuticals | [No Readings]
12 | Fear and Trauma Deadline to choose paper for final presentation | Lai C.S.W., Adler A., Gan W.B. (2018). Fear extinction reverses dendritic spine formation induced by fear conditioning in the mouse auditory cortex. PNAS, 115(37): 9306–11. Colyn L., Venzala E., Marco S., et al. (2019). Chronic social defeat stress induces sustained synaptic structural changes in the prefrontal cortex and amygdala. Behavioral Brain Research, 373, 112079: 1–7. Week 12 Reading Questions (PDF)
13 | Nedivi Lab Visit: Technique Demonstrations | Optional Reading Villa K.L., Berry K.P., Subramanian J., et al. (2016). Inhibitory synapses are repeatedly assembled and removed at persistent sites in vivo. Neuron, 89(4): 756–69.
14 | Final Oral Presentations and Wrap-up Discussion | [No Readings]

## Course Info

##### Instructors

- Dr. Dalila Ordonez
- Dr. Josiah Boivin

##### Departments

- Biology

##### As Taught In

Fall 2022

##### Level

Undergraduate

##### Topics

- Health and Medicine
  - Sensory-Neural Systems
- Science
  - Biology
    - Molecular Biology
    - Neurobiology
    - Neuroscience
  - Cognitive Science

##### Learning Resource Types

assignment Presentation Assignments
assignment Activity Assignments
assignment_turned_in Written Assignments with Examples
Readings

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