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7.341 | Spring 2022 | Undergraduate

# Turning Evolutionary Dials: Directed Evolution Techniques for Climate Change and Beyond

Description:

A 3-D illustration of the structure of the GCC enzyme.

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Alt text:
A multi-colored 3 dimensional illustration, shaped like a bumpy donut, representing the structure of an emzyme and its interconnected domains.
Caption:
Researchers used directed evolution strategies to engineer a new carbon-dioxide-fixing enzyme, glycolyl-CoA carboxylase, or GCC (above), the key enzyme of the tartronyl-COA (TaCO) pathway. Potential applications of the TaCO pathway include improving the efficiency of photosynthesis, and enhancing carbon-dioxide capture technologies. Image from the RCSB PDB of PDB ID 6YBQ (Schuller, J.M., Schuller, S.K., Zarzycki, J., Scheffen, M., Marchal, D.M., Erb, T.J. (2021) Engineered glycolyl-CoA carboxylase (quintuple mutant) with bound CoA. Nature Catalysis volume 4, pages 105–115 (2021).
Credit:
Image from the RCSB PDB of PDB ID 6YBQ (Schuller, J.M., Schuller, S.K., Zarzycki, J., Scheffen, M., Marchal, D.M., Erb, T.J. (2021) Engineered glycolyl-CoA carboxylase (quintuple mutant) with bound CoA. Nature Catalysis volume 4, pages105–115 (2021). https://www.rcsb.org/structure/6YBQ

## Course Info

##### Instructors

- Dr. Megan Kizer
- Dr. Robbie Wilson

##### Departments

- Biology

##### As Taught In

Spring 2022

##### Level

Undergraduate

##### Topics

- Science
  - Biology
    - Biochemistry
    - Cell Biology
    - Molecular Biology

##### Learning Resource Types

assignment Written Assignments
assignment Presentation Assignments

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