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Now showing items 26874-26893 of 143390
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Cytosolic Delivery of Proteins by Bioreversible Esterification
(American Chemical Society, 2017-10)Cloaking its carboxyl groups with a hydrophobic moiety is shown to enable a protein to enter the cytosol of a mammalian cell. Diazo compounds derived from (p-methylphenyl)glycine were screened for the ability to esterify ... -
Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins
(Oxford University Press (OUP), 2017-06)Protein-based methods of siRNA delivery are capable of uniquely specific targeting, but are limited by technical challenges such as low potency or poor biophysical properties. Here, we engineered a series of ultra-high ... -
Cytosolic Monothiol Glutaredoxins Function in Intracellular Iron Sensing and Trafficking via Their Bound Iron-Sulfur Cluster
(Elsevier, 2010-10)Iron is an essential nutrient for cells. It is unknown how iron, after its import into the cytosol, is specifically delivered to iron-dependent processes in various cellular compartments. Here, we identify an essential ... -
Cytosolic Uptake of Large Monofunctionalized Dextrans
(American Chemical Society (ACS), 2018-04)Dextrans are a versatile class of polysaccharides with applications that span medicine, cell biology, food science, and consumer goods. Here, we report on a new type of large monofunctionalized dextran that exhibits unusual ... -
CytoSolve: A Scalable Computational Method for Dynamic Integration of Multiple Molecular Pathway Models
(Springer-Verlag, 2010-10)A grand challenge of computational systems biology is to create a molecular pathway model of the whole cell. Current approaches involve merging smaller molecular pathway models’ source codes to create a large monolithic ... -
Cytotoxic and Pathogenic Properties of Klebsiella oxytoca Isolated from Laboratory Animals
(Public Library of Science, 2014-07)Klebsiella oxytoca is an opportunistic pathogen implicated in various clinical diseases in animals and humans. Studies suggest that in humans K. oxytoca exerts its pathogenicity in part through a cytotoxin. However, cytotoxin ... -
Cytotoxic Escherichia coli strains encoding colibactin and cytotoxic necrotizing factor (CNF) colonize laboratory macaques
(BioMed Central, 2017-12)Background: Many Escherichia coli strains are considered to be a component of the normal flora found in the human and animal intestinal tracts. While most E. coli strains are commensal, some strains encode virulence factors ... -
Cytotoxic Escherichia coli strains encoding colibactin colonize laboratory mice
(Elsevier, 2016-07)Escherichia coli strains have not been fully characterized in laboratory mice and are not currently excluded from mouse colonies. Colibactin (Clb), a cytotoxin, has been associated with inflammation and cancer in humans ... -
Cytotoxic Escherichia coli strains encoding colibactin isolated from immunocompromised mice with urosepsis and meningitis
(Public Library of Science, 2018-03)This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ... -
Cytotoxic Escherichia coli strains encoding colibactin, cytotoxic necrotizing factor, and cytolethal distending toxin colonize laboratory common marmosets (Callithrix jacchus)
(Springer Science and Business Media LLC, 2021)© 2021, The Author(s). Cyclomodulins are virulence factors that modulate cellular differentiation, apoptosis, and proliferation. These include colibactin (pks), cytotoxic necrotizing factor (cnf), and cytolethal distending ... -
Cytotoxic Escherichia coli strains encoding colibactin, cytotoxic necrotizing factor, and cytolethal distending toxin colonize laboratory common marmosets (Callithrix jacchus)
(Springer Science and Business Media LLC, 2021)© 2021, The Author(s). Cyclomodulins are virulence factors that modulate cellular differentiation, apoptosis, and proliferation. These include colibactin (pks), cytotoxic necrotizing factor (cnf), and cytolethal distending ... -
D band Raman intensity calculation in armchair edged graphene nanoribbons
(American Physical Society, 2011-06)The D band Raman intensity is calculated for armchair edged graphene nanoribbons using an extended tight-binding method in which the effect of interactions up to the seventh nearest neighbor is taken into account. The ... -
D-3He Proton Spectra for Diagnosing Shell r R and Fuel Ti of Imploded Capsules at OMEGA
(MIT Plasma Science and Fusion Center, 1999-11-22) -
A d-Amino Acid at the N-Terminus of a Protein Abrogates Its Degradation by the N-End Rule Pathway
(American Chemical Society (ACS), 2015-11)Eukaryotes have evolved the ubiquitin (Ub)/proteasome system to degrade polypeptides. The Ub/proteasome system is one way that cells regulate cytosolic protein and amino acids levels through the recognition and ubiquitination ... -
D-BigBand: sensing GHZ-wide non-sparse spectrum on commodity radios
(Association for Computing Machinery (ACM), 2014)This paper presents D-BigBand, a system that senses a GHz-wide spectrum in real time using ADCs sampling at only tens of MS/s speed. It is an advanced version of our previous work, BigBand, which senses GHz-wide sparse ... -
D-branes and string field theory
(Massachusetts Institute of Technology, 2006)In this thesis we study the D-brane physics in the context of Witten's cubic string field theory. We compute first few terms the low energy effective action for the non-abelian gauge field A, from Witten's action. We show ... -
D-branes, gauge theory and string field theory
(Massachusetts Institute of Technology, 2002)In this thesis, we present several works done in last three years. They include three directions in the string theory. In the first direction, we use the brane setup to find mirror pairs of SO(n) and Sp(k) gauge groups for ... -
D-Cyclins Repress Apoptosis in Hematopoietic Cells by Controlling Death Receptor Fas and Its Ligand FasL
(Elsevier, 2014-06)D-type cyclins (D1, D2, and D3) are components of the mammalian core cell-cycle machinery and function to drive cell proliferation. Here, we report that D-cyclins perform a rate-limiting antiapoptotic function in vivo. We ... -
D-D fusion neutron spectra measurements and ion temperature determination at Alcator C
(MIT Plasma Science and Fusion Center, 1983-01-01) -
D-D fusion neutron spectra measurements and ion temperature determination at Alcator C
(Massachusetts Institute of Technology, 1983)
