Browsing by Title
Now showing items 128856-128875 of 143233
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T cell mediated combination immunotherapy
(Massachusetts Institute of Technology, 2016)Immunotherapy is a broad treatment strategy that harnesses the immune system to fight off a particular condition or disease. Cancer immunotherapy is the specific application of agents designed to interact or stimulate the ... -
T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis
(Elsevier, 2011-08)The immunological synapse (IS) serves a dual role for sustained T cell receptor (TCR) signaling and for TCR downregulation. TC21 (Rras2) is a RRas subfamily GTPase that constitutively associates with the TCR and is implicated ... -
A T cell receptor transgenic approach to the study of thymocyte development and autoimmune disease
(Massachusetts Institute of Technology, 1999)CDS+ T lymphocytes recognize short peptide fragments when bound to self-class I major histocompatibility proteins. On a mature lymphocyte, such recognition results in activation of the T cell. On an immature thymocyte, ... -
T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
(Nature Publishing Group, 2017-11)Targeted delivery of compounds to particular cell subsets can enhance therapeutic index by concentrating their action on the cells of interest. Because attempts to target tumors directly have yielded limited benefit, we ... -
T Follicular Regulatory Cell–Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity
(The American Association of Immunologists, 2020)© 2020 by The American Association of Immunologists, Inc. T follicular regulatory (TFR) cells limit Ab responses, but the underlying mechanisms remain largely unknown. In this study, we identify Fgl2 as a soluble TFR cell ... -
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation
(Elsevier Science Ltd., 2018-11-15)In the small intestine, a niche of accessory cell types supports the generation of mature epithelial cell types from intestinal stem cells (ISCs). It is unclear, however, if and how immune cells in the niche affect ISC ... -
T Talk : a local communication channel for subway riders
(Massachusetts Institute of Technology, 2007)The goal of T Talk, is to utilize the tens of minutes of subway waiting time everyday as an opportunity for reading and appreciation of the complexity and diversity of the city, and developing an awareness of and social ... -
T(ether): spatially-aware handhelds, gestures and proprioception for multi-user 3D modeling and animation
(2014-10)T(ether) is a spatially-aware display system for multi-user, collaborative manipulation and animation of virtual 3D objects. The handheld display acts as a window into virtual reality, providing users with a perspective ... -
T(T,2n)[superscript 4]He and [superscript 3]He([superscript 3]He,2p)[superscript 4]He: The Reaction Mechanism from Solar Energies to 10 MeV*
(EDP Sciences, 2016-03)We have studied the energy dependence of the reaction mechanism of the T(t,2n)[superscript 4] He reaction at stellar energies and of its charge symmetric analog reaction [superscript 3]He([superscript 3]He,2p)[superscript ... -
T-cell death following immune activation is mediated by mitochondria-localized SARM
(Nature Publishing Group, 2012-11)Following acute-phase infection, activated T cells are terminated to achieve immune homeostasis, failure of which results in lymphoproliferative and autoimmune diseases. We report that sterile α- and heat armadillo-motif ... -
T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell
(National Academy of Sciences (U.S.), 2010-11)The conversion of mature somatic cells into pluripotent stem cells, both by nuclear transfer and transduction with specific “reprogramming” genes, represents a major advance in regenerative medicine. Pluripotent stem cell ... -
T-duality constraints on higher derivatives revisited
(Springer Berlin Heidelberg, 2016-04)We ask to what extent are the higher-derivative corrections of string theory constrained by T-duality. The seminal early work by Meissner tests T-duality by reduction to one dimension using a distinguished choice of field ... -
T-junction resonant modulators and detectors in CMOS
(Massachusetts Institute of Technology, 2016)Design of optical modulators and detectors is investigated. A new design idea is proposed for optical modulators - T-junction. The T-junction allows to decouple the Extinction Ratio from the Bandwidth and to optimize each ... -
The T-Space Model : maximizing value and revenue of transit real estate assets
(Massachusetts Institute of Technology, 2020)We founded T-Space in response to the underutilization of transit stations and the opportunity it presents itself being a high volume, small footprint space with a strong network to residential neighborhoods and employment ... -
T-TER: Defeating A2 Trojans with Targeted Tamper-Evident Routing
(ACM|ACM ASIA Conference on Computer and Communications Security, 2023-07-10) -
T1 scaling : a mathematical programming approach to Thurstonian scaling
(Cambridge, Mass. : Alfred P. Sloan School of Management, Massachusetts Institute of Technology, 1981) -
T2 Characterization of Oil-In-Water Emulsions for NMR Sensor Applications
(Massachusetts Institute of Technology, 2024-02)Fluid status assessment is an essential aspect of healthcare with implications in chronic conditions such as renal disease and congestive heart failure. Current fluid status determination techniques lack quantitative methods ... -
A T=0(2^n/2), S=0(2^n/4) Algorithm for Certain NP-Complete Problems
(1980-01)In this paper we develop a general prupose algorithm that can solve a number of NP-complete problems in time T=0(2^n/2) and space S=0(2^n/4). The algorithm can be generalized to a family of algorithms whose time and space ... -
TABASCO: A single molecule, base-pair resolved gene expression simulator
(BioMed Central Ltd, 2007-12)Background Experimental studies of gene expression have identified some of the individual molecular components and elementary reactions that comprise and control cellular behavior. Given our current understanding of gene ... -
Tabi. Tabbi. Tabique. Tabby.
(Massachusetts Institute of Technology, 2023-06)The uniqueness of tabby is based in its process of collecting local and accessible materials to produce concrete through a non-measured/estimated process. The origin of tabby as either the North African tabbi, or the ...
