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Improving predictability of cell culture processes during biologics manufacturing scale-up through hybrid modeling
(Massachusetts Institute of Technology, 2020)
In the biotechnology industry, commercial manufacturing of biologic drugs occurs in large-scale production bioreactors (15,000L), but process development occurs in lab-scale production bioreactors (2-3L). Cell culture ...
Evaluation of automated storage and retrieval in a distribution center
(Massachusetts Institute of Technology, 2020)
In the face of e-commerce growth and rising customer delivery expectations, companies must adapt to meet shorter contract shipping requirements with existing infrastructures. The "Amazon effect", an evolution resulting in ...
Reducing variations in a highly constrained environment in order to increase production capacity
(Massachusetts Institute of Technology, 2020)
Variations and the negatives effects it causes on production capacity and planning are topics of significant interest in the manufacturing communities. This research investigates the hypothesis that, when operating in a ...
Racing esports in China : CUI's business expansion plan
(Massachusetts Institute of Technology, 2020)
In recent years the racing esports industry has been of greater importance in the business world beyond the role of a cultural medium. With the industry's larger size and potential for more growth, the industry has attracted ...
A study of the Canadian property boom
(Massachusetts Institute of Technology, 2020)
Canadian real estate has experienced unprecedented rapid growth since the early 2000s. People are buying homes out of concern and hope that prices may continue to rise. The immediate consequence of this trend is the changes ...
Value of distribution-level reactive power for combined heat and power systems
(Massachusetts Institute of Technology, 2020)
As the U.S. electric grid continues to experience an increase in the penetration of distributed energy resources (DER), electric utilities are evaluating new approaches for utilizing DER to help cost-effectively maintain ...
Deploying the right technology : a framework for digital strategy and selection at the United States Postal Service to shape the future of work
(Massachusetts Institute of Technology, 2020)
With the rapid evolution of technology from more affordable hardware and data storage to artificial intelligence, companies must evolve their technology strategy to remain relevant. Federal agencies are no exception as ...
Optimizing inbound freight mode decisions
(Massachusetts Institute of Technology, 2020)
Retail manufacturers often expedite inbound freight shipments from contract manufacturing bases to their distribution centers in destination markets at high cost to improve service levels to their wholesale partners and ...
Artificial intelligence infrastructure into material attributes insights
(Massachusetts Institute of Technology, 2020)
The development of a biopharmaceutical manufacturing process involves an assessment of all possible sources of variation throughout each of the unit operations in the drive toward six sigma manufacturing. The primary goal ...
Increasing e-commerce distribution center capacity through slotting strategy
(Massachusetts Institute of Technology, 2020)
To meet increasing consumer expectations around delivery times, ecommerce retailers must take orders from 'click' to 'ship' as soon as possible. For retailers with tens of thousands of stock keeping units (SKUs), item ...