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Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii
(Wiley, 2025-02)Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals manufactured by well-established processes using Chinese Hamster Ovary (CHO) cells. Next-generation biomanufacturing using alternative hosts like ... -
Modulation of antigen delivery and lymph node activation in nonhuman primates by saponin adjuvant saponin/monophosphoryl lipid A nanoparticle
(Oxford University Press, 2024-11-25)Saponin-based vaccine adjuvants are potent in preclinical animal models and humans, but their mechanisms of action remain poorly understood. Here, using a stabilized HIV envelope trimer immunogen, we carried out studies ... -
Vaccines combining slow release and follicle targeting of antigens increase germinal center B cell diversity and clonal expansion
(American Association for the Advancement of Science, 2025-06-18)Vaccine adjuvants play important roles in shaping the humoral response to immunization. Here, we analyzed mechanisms of action of a clinically relevant combination adjuvant strategy, where phosphoserine (pSer)–tagged ...