MIT Open Access Articles

Nanoparticle‐Mediated Delivery of Anti‐PU.1 siRNA via Localized Intracisternal Administration Reduces Neuroinflammation

Ralvenius, William T; Andresen, Jason L; Huston, Margaret M; Penney, Jay; Bonner, Julia Maeve; e.a. (Wiley, 2024-02-22)

Neuroinflammation is a hallmark of neurodegenerative disorders including Alzheimer's disease (AD). Microglia, the brain's immune cells, express many of the AD‐risk loci identified in genome wide association studies and ...
CRISPR–Cas9 delivery strategies for the modulation of immune and non-immune cells

Alsaiari, Shahad K; Eshaghi, Behnaz; Du, Bujie; Kanelli, Maria; Li, Gary; e.a. (Springer Science and Business Media LLC, 2024-10-16)

CRISPR–Cas9 genome editing technology is a promising tool for genetically engineering immune cells and modulating immune systems. Although ex vivo genome editing of immune cells has reached clinical trials, in vivo application ...
Degradable poly(β-amino ester) microparticles for cleansing products and food fortification

Zhang, Linzixuan; Xiao, Ruiqing; Jin, Tianyi; Pan, Xinyan; Fransen, Katharina A; e.a. (Springer Science and Business Media LLC, 2024)

Microplastic pollution is a pressing global crisis caused by the extensive use of nondegradable microplastic materials in daily activities. One effective approach to mitigate this issue is to replace nondegradable plastics ...