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The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined

Author(s)
Jiang, Haoran; Kittipibul, Veraprapas; Mahfoud, Felix; Böhm, Michael; Sobotka, Paul A.; Esler, Murray; Wang, Jie; Fudim, Marat; ... Show more Show less
Download10741_2024_10463_ReferencePDF.pdf (Embargoed until: 2025-08-07, 1.014Mb)
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.

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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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Abstract
Activation of the sympathetic nervous system has been attributed to the development of hypertension. Two established approaches for treating hypertension are pharmacotherapy and lifestyle changes. With an improved understanding of renal nerve anatomy and physiology, renal denervation has been proposed as an alternative treatment for hypertension. Specifically, it has been shown that the interruption of sympathetic nerves connecting the kidney and the sympathetic nervous system can reduce blood pressure. Here, we present a review on how renal denervation can help hypertension patients, specifically focusing on our novel understanding of renal nerve anatomy, denervation technique, and subsequent clinical trials, and how it may be used to treat other cardiovascular diseases like heart failure.
Date issued
2024-11-07
URI
https://hdl.handle.net/1721.1/159671
Department
Institute for Medical Engineering and Science
Journal
Heart Failure Reviews
Publisher
Springer US
Citation
Jiang, H., Kittipibul, V., Mahfoud, F. et al. The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined. Heart Fail Rev 30, 293–314 (2025).
Version: Author's final manuscript

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