MIT Open Access Articles: Recent submissions

Now showing items 121-123 of 55794

    • PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion 

      Pauken, Kristen E; Markson, Samuel C; Conway, Thomas S; Juneja, Vikram R; Shahid, Osmaan; e.a. (Rockefeller University Press, 2025-10-06)
      Although PD-1 inhibitors are FDA-approved for over 25 different cancers, the mechanisms contributing to response remain incompletely understood. To investigate how PD-1–deleted CD8+ T cells influence PD-1–expressing CD8+ ...

    • A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation 

      Ralvenius, William T; Mungenast, Alison E; Woolf, Hannah; Huston, Margaret M; Gillingham, Tyler Z; e.a. (Rockefeller University Press, 2023-11-06)
      Pervasive neuroinflammation occurs in many neurodegenerative diseases, including Alzheimer’s disease (AD). SPI1/PU.1 is a transcription factor located at a genome-wide significant AD-risk locus and its reduced expression ...

    • Remodeling of colon plasma cell repertoire within ulcerative colitis patients 

      Scheid, Johannes F; Eraslan, Basak; Hudak, Andrew; Brown, Eric M; Sergio, Dallis; e.a. (Rockefeller University Press, 2023-04-03)
      Plasma cells (PCs) constitute a significant fraction of colonic mucosal cells and contribute to inflammatory infiltrates in ulcerative colitis (UC). While gut PCs secrete bacteria-targeting IgA antibodies, their role in ...