Browsing MIT Open Access Articles by Title
Now showing items 50187-50206 of 55948
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T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis
(Elsevier, 2011-08)The immunological synapse (IS) serves a dual role for sustained T cell receptor (TCR) signaling and for TCR downregulation. TC21 (Rras2) is a RRas subfamily GTPase that constitutively associates with the TCR and is implicated ... -
T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
(Nature Publishing Group, 2017-11)Targeted delivery of compounds to particular cell subsets can enhance therapeutic index by concentrating their action on the cells of interest. Because attempts to target tumors directly have yielded limited benefit, we ... -
T Follicular Regulatory Cell–Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity
(The American Association of Immunologists, 2020)© 2020 by The American Association of Immunologists, Inc. T follicular regulatory (TFR) cells limit Ab responses, but the underlying mechanisms remain largely unknown. In this study, we identify Fgl2 as a soluble TFR cell ... -
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation
(Elsevier Science Ltd., 2018-11-15)In the small intestine, a niche of accessory cell types supports the generation of mature epithelial cell types from intestinal stem cells (ISCs). It is unclear, however, if and how immune cells in the niche affect ISC ... -
T(ether): spatially-aware handhelds, gestures and proprioception for multi-user 3D modeling and animation
(2014-10)T(ether) is a spatially-aware display system for multi-user, collaborative manipulation and animation of virtual 3D objects. The handheld display acts as a window into virtual reality, providing users with a perspective ... -
T(T,2n)[superscript 4]He and [superscript 3]He([superscript 3]He,2p)[superscript 4]He: The Reaction Mechanism from Solar Energies to 10 MeV*
(EDP Sciences, 2016-03)We have studied the energy dependence of the reaction mechanism of the T(t,2n)[superscript 4] He reaction at stellar energies and of its charge symmetric analog reaction [superscript 3]He([superscript 3]He,2p)[superscript ... -
T-cell death following immune activation is mediated by mitochondria-localized SARM
(Nature Publishing Group, 2012-11)Following acute-phase infection, activated T cells are terminated to achieve immune homeostasis, failure of which results in lymphoproliferative and autoimmune diseases. We report that sterile α- and heat armadillo-motif ... -
T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell
(National Academy of Sciences (U.S.), 2010-11)The conversion of mature somatic cells into pluripotent stem cells, both by nuclear transfer and transduction with specific “reprogramming” genes, represents a major advance in regenerative medicine. Pluripotent stem cell ... -
T-duality constraints on higher derivatives revisited
(Springer Berlin Heidelberg, 2016-04)We ask to what extent are the higher-derivative corrections of string theory constrained by T-duality. The seminal early work by Meissner tests T-duality by reduction to one dimension using a distinguished choice of field ... -
T-TER: Defeating A2 Trojans with Targeted Tamper-Evident Routing
(ACM|ACM ASIA Conference on Computer and Communications Security, 2023-07-10) -
TABASCO: A single molecule, base-pair resolved gene expression simulator
(BioMed Central Ltd, 2007-12)Background Experimental studies of gene expression have identified some of the individual molecular components and elementary reactions that comprise and control cellular behavior. Given our current understanding of gene ... -
tableone: An open source Python package for producing summary statistics for research papers
(Oxford University Press (OUP), 2018-05)Objectives:In quantitative research, understanding basic parameters of the study population is key for interpre-tation of the results. As a result, it is typical for the first table (“Table 1”) of a research paper to include ... -
Tablets, Pens, and Pencils: The Influence of Tools on Sketching in Early Stage Design
(American Society of Mechanical Engineers, 2022-08-14)<jats:title>Abstract</jats:title> <jats:p>Sketching is often used as a tool during idea generation in the early stages of engineering design. At the same time, the rapid increase in remote engineering and ... -
Tabula Rasaforn-Cz silicon-based photovoltaics
(Wiley, 2018-08)High-temperature annealing, known as Tabula Rasa (TR), proves to be an effective method for dissolving oxygen precipitate nuclei in n-Cz silicon and makes this material resistant to temperature-induced and process-induced ... -
TabulaROSA: Tabular Operating System Architecture for Massively Parallel Heterogeneous Compute Engines
(Institute of Electrical and Electronics Engineers (IEEE), 2018-11)The rise in computing hardware choices is driving a reevaluation of operating systems. The traditional role of an operating system controlling the execution of its own hardware is evolving toward a model whereby the ... -
Tachyon: Reliable, Memory Speed Storage for Cluster Computing Frameworks
(Association for Computing Machinery (ACM), 2014-11)Tachyon is a distributed file system enabling reliable data sharing at memory speed across cluster computing frameworks. While caching today improves read workloads, writes are either network or disk bound, as replication ... -
Tackling Climate Change with Machine Learning
(ACM, 2022-02-08) -
Tackling the cancer stem cells — what challenges do they pose?
(Nature Publishing Group, 2014-07)Since their identification in 1994, cancer stem cells (CSCs) have been objects of intensive study. Their properties and mechanisms of formation have become a major focus of current cancer research, in part because of their ... -
Taco: A tool to generate tensor algebra kernels
(IEEE, 2017-10)Tensor algebra is an important computational abstraction that is increasingly used in data analytics, machine learning, engineering, and the physical sciences. However, the number of tensor expressions is unbounded, which ... -
Taco: A tool to generate tensor algebra kernels
(IEEE, 2017-10)Tensor algebra is an important computational abstraction that is increasingly used in data analytics, machine learning, engineering, and the physical sciences. However, the number of tensor expressions is unbounded, which ...
