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Regulation of thymocyte positive selection and motility by GIT2
(Nature Publishing Group, 2010-05)
Thymocytes are highly motile cells that migrate under the influence of chemokines in distinct thymic compartments as they mature. The motility of thymocytes is tightly regulated; however, the molecular mechanisms that ...
CXCR4-expressing Mist1+ progenitors in the gastric antrum contribute to gastric cancer development
(Impact Journals, LLC, 2017-11)
Mist1 was recently shown to identify a discrete population of stem cells within the isthmus of the oxyntic gland within the gastric corpus. Chief cells at the base of the gastric corpus also express Mist1. The relevance ...
Potential drivers of virulence evolution in aquaculture
(Wiley Blackwell, 2016-02)
Infectious diseases are economically detrimental to aquaculture, and with continued expansion and intensification of aquaculture, the importance of managing infectious diseases will likely increase in the future. Here, we ...
Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies
(American Association of Pharmaceutical Scientists, 2017-07)
Investigation of the pharmacokinetics (PK) of a compound is of significant importance during the early stages of drug development, and therefore several in vitro systems are routinely employed for this purpose. However, ...
Engineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells
(Springer Science and Business Media LLC, 2018-10)
The development of RNA-encoded regulatory circuits relying on RNA-binding proteins (RBPs) has enhanced the applicability and prospects of post-transcriptional synthetic network for reprogramming cellular functions. However, ...
Hesitant steps from the artificial skin to organ regeneration
(Oxford University Press (OUP), 2018-06)
This is a historical account of the steps, both serendipitous and rational, that led my group of students and colleagues at MIT and Harvard Medical School to discover induced organ regeneration. Our research led to methods ...
Online reporting for malaria surveillance using micro-monetary incentives, in urban India 2010-2011
(BioMed Central Ltd, 2012-02)
Background The objective of this study was to investigate the use of novel surveillance tools in a malaria endemic region where prevalence information is limited. Specifically, online reporting for participatory epidemiology ...
Investigating Effects of Proteasome Inhibitor on Multiple Myeloma Cells Using Confocal Raman Microscopy
(MDPI AG, 2016-12)
Due to its label-free and non-destructive nature, applications of Raman spectroscopic imaging in monitoring therapeutic responses at the cellular level are growing. We have recently developed a high-speed confocal Raman ...
Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations
(Nature Publishing Group, 2016-11)
Recent drug discovery and development efforts have created a large arsenal of targeted and chemotherapeutic drugs for precision medicine. However, drug resistance remains a major challenge as minor pre-existing resistant ...
Discrete logic modelling as a means to link protein signalling networks functional analysis of mammalian signal transduction
(EMBO and Macmillan Publishers Limited, 2009-12)
Large-scale protein signalling networks are useful for exploring complex biochemical pathways but do not reveal how pathways respond to specific stimuli. Such specificity is critical for understanding disease and designing ...