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Identification of the minimal bacterial 2′-deoxy-7-amido-7-deazaguanine synthesis machinery
(Wiley, 2018-10-12)
The 7-deazapurine derivatives, 2′-deoxy-7-cyano-7-deazaguanosine (dPreQ0) and 2′-deoxy-7-amido-7-deazaguanosine (dADG) are recently discovered DNA modifications encoded by the dpd cluster found in a diverse set of bacteria. ...
Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling
(American Association for the Advancement of Science (AAAS), 2011-06-28)
The timing and localization of events during mitosis are controlled by the regulated phosphorylation of proteins by the mitotic kinases, which include Aurora A, Aurora B, Nek2 (never in mitosis kinase 2), Plk1 (Polo-like ...
Structural and dynamic basis of substrate permissiveness in hydroxycinnamoyltransferase (HCT)
(Public Library of Science (PLoS), 2018-10-26)
Substrate permissiveness has long been regarded as the raw materials for the evolution of new enzymatic functions. In land plants, hydroxycinnamoyltransferase (HCT) is an essential enzyme of the phenylpropanoid metabolism. ...
TGF-β signaling in cellular senescence and aging-related pathology
(MDPI AG, 2019-10-10)
Aging is broadly defined as the functional decline that occurs in all body systems. The accumulation of senescent cells is considered a hallmark of aging and thought to contribute to the aging pathologies. Transforming ...
Casting a wider net: Immunosurveillance by nonclassical MHC molecules
(Public Library of Science (PLoS), 2019-02-21)
Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological ...
Sequestration of microRNA-mediated target repression by the Ago2-associated RNA-binding protein FAM120A
(Cold Spring Harbor Laboratory Press, 2019-07-09)
Argonaute (Ago) proteins interact with various binding partners and play a pivotal role in microRNA (miRNA)-mediated silencing pathways. By utilizing immunoprecipitation followed by mass spectrometry to determine cytoplasmic ...
Identification of cell cycle-targeting microRNAs through genome-wide screens
(Informa UK Limited, 2017-11-14)
By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting ...
Alzheimer’s Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?
(MDPI AG, 2024-03-31)
The amyloid cascade hypothesis for Alzheimer’s disease is still alive, although heavily challenged. Effective anti-amyloid immunotherapy would confirm the hypothesis’ claim that the protein amyloid-beta is the ...
Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management
(MDPI AG, 2024-03-29)
The persistent failure of standard chemotherapy underscores the urgent need for innovative and targeted approaches in cancer treatment. Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach ...
A Bayesian model of acquisition and clearance of bacterial colonization incorporating within-host variation
(Public Library of Science (PLoS), 2019-04-22)
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...