MIT Open Access Articles: Recent submissions
Now showing items 1-3 of 55010
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Engineering peroxisomal biosynthetic pathways for maximization of triterpene production in Yarrowia lipolytica
(Proceedings of the National Academy of Sciences, 2024-01-23)Constructing efficient cell factories for product synthesis is frequently hampered by competing pathways and/or insufficient precursor supply. This is particularly evident in the case of triterpenoid biosynthesis in Yarrowia ... -
Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy
(American Society for Clinical Investigation, 2024-05-30)The nonphysiological nutrient levels found in traditional culture media have been shown to affect numerous aspects of cancer cell physiology, including how cells respond to certain therapeutic agents. Here, we comprehensively ... -
Metabolic Engineering of E. coli for Enhanced Diols Production from Acetate
(American Chemical Society, 2025-04-18)Effective employment of renewable carbon sources is highly demanded to develop sustainable biobased manufacturing. Here, we developed Escherichia coli strains to produce 2,3-butanediol and acetoin (collectively referred ...