MIT Open Access Articles: Recent submissions
Now showing items 43-45 of 55432
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Identification and Validation of Cyclic Peptides with Mucin-Selective, Location-Specific Binding in the Gastrointestinal Tract
(American Chemical Society, 2025-04-11)Oral drug delivery is a widely preferred method of drug administration due to its ease of use and convenience for patients. Localization of drug release in the gastrointestinal (GI) tract is important to treat localized ... -
Pd-Catalyzed Amination of Base-Sensitive Five-Membered Heteroaryl Halides with Aliphatic Amines
(American Chemical Society, 2023-01-31)We report a versatile and functional-group-tolerant method for the Pd-catalyzed C–N cross-coupling of five-membered heteroaryl halides with primary and secondary amines, an important but underexplored transformation. ... -
Abiotic peptides as carriers of information for the encoding of small-molecule library synthesis
(American Association for the Advancement of Science, 2023-03-02)Encoding small-molecule information in DNA has been leveraged to accelerate the discovery of ligands for therapeutic targets such as proteins. However, oligonucleotide-based encoding is hampered by inherent limitations of ...
