MIT Open Access Articles: Recent submissions
Now showing items 511-513 of 55794
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Intratumoral nanobody–IL-2 fusions that bind the tumor extracellular matrix suppress solid tumor growth in mice
(Oxford University Press, 2022-11)Confining cytokine exposure to the tumors would greatly enhance cancer immunotherapy safety and efficacy. Immunocytokines, cytokines fused to tumor-targeting antibodies, have been developed with this intention, but without ... -
Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer
(Springer Science and Business Media LLC, 2023-08-09)Background Genetically engineered mouse models (GEMMs) of cancer are powerful tools to study mechanisms of disease progression and therapy response, yet little is known about how these models respond to multimodality ... -
Anti–PD-1 and Extended Half-life IL2 Synergize for Treatment of Murine Glioblastoma Independent of Host MHC Class I Expression
(American Association for Cancer Research, 2023-06-02)Glioblastoma (GBM) is the most common malignant brain tumor in adults, responsible for approximately 225,000 deaths per year. Despite preclinical successes, most interventions have failed to extend patient survival by more ...
