MIT Open Access Articles: Recent submissions
Now showing items 514-516 of 55794
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Collagen-Anchored Interleukin-2 and Interleukin-12 Safely Reprogram the Tumor Microenvironment in Canine Soft-Tissue Sarcomas
(American Association for Cancer Research, 2023-06-01)Purpose: Cytokine therapies such as IL2 and IL12 suffer from impractically small therapeutic windows driven by their on-target, off-tumor activity, limiting their clinical potential despite potent antitumor effects. We ... -
Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies
(Proceedings of the National Academy of Sciences, 2023-07-24)Anti-CTLA-4 antibodies have successfully elicited durable tumor regression in the clinic; however, long-term benefit is limited to a subset of patients for select cancer indications. The incomplete understanding of their ... -
Overcoming lung cancer immunotherapy resistance by combining nontoxic variants of IL-12 and IL-2
(American Society for Clinical Investigation, 2023-09-05)Engineered cytokine-based approaches for immunotherapy of cancer are poised to enter the clinic, with IL-12 being at the forefront. However, little is known about potential mechanisms of resistance to cytokine therapies. ...
